369 Inception

🤣
This snake oil isn't even worth commenting on.

The only things that actually work are Finasteride, Dutasteride, Minoxidil, RU58841, and PRP. Further, GHK-Cu is meant to be injected. Stick to a proper health regimen, and if you still want more hair, just get a transplant.

JohnnyDoe said:

🤣
This snake oil isn't even worth commenting on.

The only things that actually work are Finasteride, Dutasteride, Minoxidil, RU58841, and PRP. Further, GHK-Cu is meant to be injected. Stick to a proper health regimen, and if you still want more hair, just get a transplant.

What about stem cells on the scalp?

PS. I've gone to Puerto Vallarta, Mexico for stem cells (not for alopecia, though)

jafo said:

What about stem cells on the scalp?

Overhyped and wildly overpriced.
At best, stem cells on the scalp act like an expensive version of PRP. You might get some growth factors to temporarily stimulate miniaturizing follicles, but it does absolutely nothing to address the actual mechanism: DHT. If you aren't inhibiting 5-alpha reductase, your follicles will keep choking to death regardless of what you inject into your head.

Further, if an area is already slick bald, no amount of stem cells will resurrect a dead follicle from the grave. Only a transplant (or a toupee) puts hair where there is none.
Stick to blocking DHT, or save that money for Turkey.

jafo said:

PS. I've gone to Puerto Vallarta, Mexico for stem cells (not for alopecia, though)

Clinics down there have a fantastic business model charging thousands of dollars for umbilical cord cocktails because the local regulatory environment lets them sell whatever they want. It might have some merit for systemic inflammation or damaged joints.

JohnnyDoe said:

It might have some merit for systemic inflammation or damaged joints.

It does! Pre and post knee (17 months apart) and shoulder MRI confirmed this. Of course, I go to the same place Ronnie Coleman goes. The owner of the place tries his best.

jafo said:

It does! Pre and post knee (17 months apart) and shoulder MRI confirmed this. Of course, I go to the same place Ronnie Coleman goes. The owner of the place tries his best.

Sorry but correlation is not causation. Two MRIs taken 17 months apart only prove that the human body heals and remodels on its own given a year and a half of time, rest, and rehab, not that an overpriced umbilical cord cocktail did the work. Joint effusion, bone marrow edema, and minor soft tissue tears naturally resolve over that timeframe without injecting anything.

Further, the peer reviewed data says the exact opposite of what Mexican clinics claim. In the largest Phase 3 randomized controlled trial on this, the famous MILES study led by Emory and Duke (Mautner et al., Nature Medicine, 2023, 480 patients), researchers tested three different stem cell sources, including the exact umbilical cord MSCs sold in Puerto Vallarta, head to head against a standard corticosteroid shot. After 12 months, stem cells showed zero superiority over a cheap steroid injection, and follow up MRIs showed zero structural improvement in the joint. Newer placebo controlled trials (such as ADIPOA2 in 2025) and the 2025 Cochrane review confirmed the same thing: on an MRI, stem cells don't regenerate cartilage any better than a saline placebo.

As for going to the same clinic as Ronnie Coleman (Regenamex), taking medical cues from a celebrity sponsorship is not the smartest thing to do. Ronnie gets comped treatments to promote them on Instagram, and while the owner might "try his best”, good intentions don't turn Wharton's jelly into new cartilage. Though I have no doubt he tries his very best when issuing the invoice 🤣